Antigenspecific immunotherapy for type 1 diabetes

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In type 1 diabetes, islet-specific self-antigens are presented to CD8+ T effector cells (Teffs) by antigen-presented cells (APC) in the lymph nodes. The Teffs ultimately destroy beta cells in the islet of Langerhans in the pancreas. Antigen-specific immunotherapy (ASI) has been proposed as an alternative treatment strategy for type 1 diabetes (T1D). ASI aims to induce a regulatory, rather than stimulatory, immune response in order to reduce, or prevent, autoimmune mediated β-cell destruction, thus preserving endogenous insulin production. In the immunotherapy diabetes (IMDIAB) trial, a total of 82 patients with clinical type 1 diabetes were randomized to receive oral insulin at 5 mg/day or placebo (Pozzilli et al., 2000). At a 1 year follow-up, there was no difference between the insulin-treated and the placebo-treated groups with respect to mean C-peptide secretion, requirement. Type 1 diabetes immunotherapy using polyclonal regulatory T cells. Sci Transl Med 2015;7:315ra189. doi: 10.1126/scitranslmed.aad4134 [2] Ali MA, Liu Y-F, Arif S et al. Antigen-specific immunotherapy of type 1 diabetes, via delivery of a one indigenous cell antigen typically, provides had small scientific benefit to date. of all Testosterone levels?cells was achieved with segregation of Compact disc4 and Compact disc8 epitopes, the last mentioned containing mimotopes and driven by endosome-targeting indicators, after delivery into either dendritic or stromal.
Autoantigen treatment has been tried for the prevention of type 1 diabetes (T1D) and to preserve residual beta-cell function in patients with a recent onset of the disease. In experimental animal models, efficacy was good, but was insufficient in human ...
Immunotherapeutic strategies under consideration for type 1 diabetes include modification of the autoimmune response through antigen‐specific routes. Administration of short peptides representing T c...
Autoantigen treatment has been tried for the prevention of type 1 diabetes (T1D) and to preserve residual beta-cell function in patients with a recent onset of the disease. In experimental animal models, efficacy was good, but was insufficient in human ...
PATHOGENESIS OF TYPE 1 DIABETES (A PUGLIESE AND SJ RICHARDSON, SECTION EDITORS) AQuestionofTolerance—Antigen-Specific Immunotherapy for Type 1 Diabetes Jeniffer D.
The Immune Tolerance Network and Juvenile Diabetes Research Foundation Joint Taskforce as well as recent commentaries, have opined that ideal immunotherapies for type 1 diabetes (T1D) should reduce proinflammatory autoimmune responses, promote regulatory responses, and enhance β-cell survival and replication ( 1 - 4 ).